Figure 5: sAPP-α reduces β-amyloid pathology in a mouse model of AD.
From: Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation
(a) Mouse brain sections from PSAPP and PSAPP/TgsAPP-α mice were stained with anti-Aβ17−24 antibody [4G8: brown, up (scale bar: 50 μm) and middle panels (scale bar: 50 μm)] or Thioflavin S [ThioS: green signal, bottom panel (scale bar: 50 μm)] at 8 months of age. (b) Mouse brain sections from PSAPP and PSAPP/TgsAPP-α mice were stained with Aβ OC antibody (brown signal). (c) Percentage of Aβ OC antibody immunoreactive plaques from hippocampus and cortex (mean±s.d.; n=5 females per group) was quantified by image analysis. A t-test c for independent samples revealed significances between groups (**P<0.01).
