Table 1 Serum parameters in chow diet or HFD-fed control and FIGIRKO mice.

From: Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling

 

Chow diet

High-fat diet

 

Control

FIGIRKO

Control

FIGIRKO

Insulin (ng ml−1)

0.86±0.10

0.98±0.13

1.40±0.58

8.42±3.25*

IGF-1 (ng ml−1)

560±32

475±24

387±47

402±29

TG (mg dl−1)

67±11

88±12

89±6

144±27

FFA (mEq ml−1)

1.92±0.19

2.36±0.17

1.54±0.25

2.70±0.58

Cholesterol (mg dl−1)

109±5

109±7

169±11

157±21

Leptin (ng ml−1)

4.7±0.8

2.7±0.4*

20.8±6.1

8.4±1.8*

Resistin (ng ml−1)

1.28±0.12

1.22±0.07

0.74±0.08

0.33±0.08*

Adiponectin (μg ml−1)

22.3±2.5

18.4±3.0

17.9±1.2

10.5±1.4*

TNFα (pg ml−1)

3.9±0.3

4.4±0.3

4.2±0.3

4.8±0.6

PAI-1 (ng ml−1)

0.95±0.14

0.82±0.13

1.49±0.10

1.44±0.48

IL6 (pg ml−1)

7.6±0.5

9.7±2.1

9.0±1.8

9.3±2.2

  1. Circulating concentrations were measured in control and FIGIRKO male mice fed a regular chow diet or HFD for 4 months (6–10 animals per group) in the fed state. Results are mean±s.e.m. Statistical significance assessed by two-tailed Student's t-test, *P<0.05 between control and FIGIRKO mice.
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