Figure 5: Long-term in vivo telemetric ECG in adult TN-XXL transgenic mice.
From: Biocompatibility of a genetically encoded calcium indicator in a transgenic mouse model
(a) Representative lead II ECG traces of TN-XXL and WT mice obtained by telemetric measurements at a resting heart rate of 500 b.p.m. Definitions of the ECG parameters (PQ, P, QRS, ST, QT) are indicated as specified in the methods section. Note the biphasic and prolonged p wave indicating atrial hypertrophy. (b) Heart rate analysis of transgenic (TN-XXL) and wild-type controls (WT). Minimum (min), mean and maximum (max) heart rates were calculated from the 24 h ECG. Iso=maximum heart rate after i.p. injection of isoprenaline (0.1 mg kg−1 body weight). (c) ECG parameters at a heart rate of 500 b.p.m. Letters on the X axis refer to the different phases in the ECG as indicated in panel A. Throughout, error bars represent SEM; *P<0.05; **P<0.01; ***P<0.001; n=6 mice per group. Significance was tested by analysis of variance (ANOVA) followed by Dunett test.
