Table 1 Genes regulated in TN-XXL mice.
From: Biocompatibility of a genetically encoded calcium indicator in a transgenic mouse model
Gene name | Fold change | Biological function |
|---|---|---|
Genes regulated in skeletal muscle | ||
Mt2 | 8.23 | Cellular zinc and copper ion homeostasis; nitric oxide-mediated signal transduction; radical scavenging |
Tmem28 | 7.25 | Unknown |
H19 | 6.01 | Cell proliferation |
Rabl4 | 5.93 | Small GTPase-mediated signal transduction |
Snai3 | 5.91 | DNA-dependent regulation of transcription; zinc ion binding |
Nr4a3 | 5.10 | Positive regulation of transcription from RNA polymerase II promoter; neuromuscular process controlling; zinc ion binding |
Ak3l1 | 4.83 | Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
Slc16a10 | −5.20 | Unknown; involved in transport |
Kcnf1 | −5.77 | Potassium ion transport; ion channel activity; potassium ion binding |
Adcy2 | −6.31 | cAMP biosynthetic process and G-protein signaling; activation of adenylate cyclase; magnesium ion binding; DNA binding |
Genes regulated in heart | ||
Tmem56 | 5.77 | Unknown |
Kcnk1 | 5.09 | Potassium ion transport; voltage-gated ion channel activity; potassium channel activity; the product of this gene has not been shown to be a functional channel |
Arrdc2 | 4.64 | Unknown |
Ddit4l | 3.83 | Negative regulation of signal transduction |
Wee1 | 3.68 | Cell cycle; protein phosphorylation; kinase and transferase activity |
Itgb1bp3 | 3.39 | Integrin-mediated signaling pathway; negative regulation of myoblast differentiation; kinase and transferase activity |
Spon2 | −3.14 | Immune response; cell adhesion; protein binding |
Fam124b | −3.44 | Unknown |
Nfil3 | −3.69 | DNA-dependent regulation of transcription; protein dimerization activity |
Adam19 | −3.73 | Heart development; cell migration and adhesion, membrane protein proteolysis; integrin-mediated signaling pathway; metallopeptidase activity; hydrolase activity; zinc ion binding |
