Figure 1: METTL21D is a lysine-specific class I MTase.
From: Lysine methylation of VCP by a member of a novel human protein methyltransferase family
(a) Alignment of METTL21D protein sequences (H. sapiens, NP_078834; A. pisum, XP_001945214.1; C. elegans, NP_001122759.1; N. vectensis, XP_001636505.1; Arabidopsis thaliana, NP_973791.1; Chlamydomonas reinhardtii, XP_001692568.1). Predicted α-helices and β-strands of human METTL21D are indicated. Hallmark motifs are boxed. Key residues Asp96 and Asp144 are indicated by asterisks. (b) METTL21D methylates lysine-containing, positively charged model substrates. Data are represented as means ±s.d., n=3.
