Figure 3: Effect of MPC088 on α1β3γ2 and α4β3δ GABAAR-expressing oocytes.
From: Robust photoregulation of GABAA receptors by allosteric modulation with a propofol analogue
Data in each group obtained from four oocytes. (a) Aggregate concentration–response data (mean±s.d.) obtained from α1β3γ2 (black) and α4β3δ (red) receptors with co-applied GABA at similar ~EC8 dose (that is, 3 μM for the former and 0.05 μM for the latter receptor type) and varying concentrations of trans-dominant MPC088. Response amplitudes obtained from each oocyte normalized to its saturating GABA response (that is, responses obtained with 1,000 μM GABA for α1β3γ2 and 100 μM GABA for α4β3δ GABAARs). (b) Aggregate concentration–response data (mean±s.d.) obtained from α1β3γ2 (black) and α4β3δ (red) receptors with trans-dominant MPC088 alone. Data similarly normalized to the saturating GABA response obtained from each oocyte. Results for α1β2γ2 GABAARs in a and b (blue) reproduced from those of Figs 1c and 2b, respectively.
