Figure 2: miR-941 sequence evolution.
Alignment of the genomic regions containing miR-941 precursors between the human, chimpanzee, rhesus macaque (Indian and Chinese) and Denisova genome (a). For the Denisova genome, sequence read coverage is shown. miR-941 precursor locations in the human genome are drawn based on the miRBase annotation. Secondary structure of transcripts corresponding to the miR-941 precursor sequence from the human, Denisova, chimpanzee, rhesus macaque (Indian and Chinese) genomes (b). Locations of the mature miR-941 (red) and miR-941-star (blue) sequences in the human precursor sequence and their corresponding locations in the other species' precursors are shown. RNA-seq read coverage of the mature miR-941 (red) and miR-941-star (blue) in human tissues (prefrontal cortex and cerebellum), AGO co-immunoprecipitations experiments and human cell lines (c). The complete list of data sets used is listed in Supplementary Table S3.
