Table 1 Permeability ratios of WT PKD1L3/TRPP3 and the listed mutant channels for dimethylamine+, trimethylamine+ and Mg2+.
From: Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex
Dimethylamine + | Trimethylamine + | Mg 2+ | ||||
|---|---|---|---|---|---|---|
Channel type | ΔE rev ±s.d. (n) | P dimethylamine /P Na | ΔE rev ±s.d. (n) | P trimethylamine /P Na | ΔE rev±s.d. ( n) | P Mg /P Na |
Wild type | −23.6±5.3 (55) | 0.39 | −46.6±8.4 (54) | 0.16 | −5.4±3.7 (49) | 0.65 |
TRPP3_D523Q | −8.1±4.1 (8) | 0.73 | −16.6±8.9 (9) | 0.52 | −23.1±9.1 (8) | 0.27 |
TRPP3_D525K | −12.2±6.9 (11) | 0.62 | −13±4.7 (10) | 0.60 | −12.6±9.1 (9) | 0.45 |
PKD1L3_T2067D | −4.8±1.2 (10) | 0.83 | −16.3±4.6 (8) | 0.53 | 13.2±5.4 (11) | 1.91 |
PKD1L3_T2067P | −2.2±0.8 (7) | 0.92 | −9.7±2.9 (7) | 0.68 | −25.2±4.8 (10) | 0.24 |
PKD1L3_K2069D | −4±0.7 (7) | 0.85 | −13.8±2.2 (7) | 0.58 | 22.6±0.8 (6) | 3.46 |
PKD1L3_E2072A | −26.8±2.7 (7) | 0.35 | −51.4±9 (6) | 0.13 | −15.5±1.2 (7) | 0.39 |
