Figure 1: Clinical significance of miR-17-5p expression levels in CRC patients. | Nature Communications

Figure 1: Clinical significance of miR-17-5p expression levels in CRC patients.

From: Elevated oncofoetal miR-17-5p expression regulates colorectal cancer progression by repressing its target gene P130

Figure 1

(a) miRNA array assays and qRT–PCR validation for miR-17-5p expression in CRC, foetal and colorectal tissues, and in tissues with varying degrees of dysplasia. (b) The miR-17-5p expression levels in cohort 1 were measured by qRT–PCR. (c) The miR-17-5p expression in colorectal epithelial cells using ISH analysis. (d) In cohort 2, high miR-17-5p expression was associated with reduced survival. (e) Associations between miR-17-5p expression and the therapeutic outcomes in stage II (n=126) and stage III (n=69) CRC patients in cohort 1 treated with adjuvant chemotherapy. (f) Associations between miR-17-5p expression and the therapeutic outcomes in stage II (n=99) and stage III (n=58) CRC patients in cohort 1 treated with adjuvant chemotherapy. All bars represent the mean values±s.d. of three experiments.

Back to article page