Figure 5: Kinetics of individual conductance levels.
(a) Average probability at every time point for each conducting state from idealized records (dots, only first 100 ms shown), and fits to the equation ΣiAi[1−exp(−t/τi)] (lines, see Supplementary Table S2). The first 40 ms period is shown on the right after normalizing the fits to illustrate the relative kinetics of the initial rise in probability for each level. (b) Average conditional probability at every time point after aligning the idealized records so that the first event in each sweep occurs at time zero (dots), and fits to the equation ΣiAi exp(−t/τi)+ constant (lines, see Supplementary Table S2). (c) The probability of transitioning between each conductance level during activation gating at each potential tested (0.5 ms resolution).
