Figure 4: Stictic acid docked into open L1/S3 pocket of p53 variants.
From: Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53
Stictic acid could dock favourably into the open L1/S3 pocket of MD-generated snapshots for all four p53 variants studied: (a) wt p53; (b) R175H; (c) R273H; (d) G245S. Only polar hydrogens of stictic acid are depicted here. Colours are as in Fig. 2.
