Table 1 List of protein-coding mutations in hiPSC lines.
Sample | Chromosome | Position | Gene | Alleles | Protein change | Mutation type | SIFT functional prediction | Mutated in cancer? |
|---|---|---|---|---|---|---|---|---|
ASThiPS4F4 | 6 | 31783527 | LY6G6F | GAC-GAt | D122D | Synonymous | NA | Yes |
ASThiPS4F4 | 8 | 68087821 | LRRC67 | CTT-aTT | L121I | Non-synonymous | TOLERATED | No |
ASThiPS4F5 | 11 | 54891946 | OR4A15 | CTG-CcG | L4P | Non-synonymous | DAMAGING | No |
ASThiPS4F5 | 13 | 110343392 | ANKRD10 | AAG-AAt | K225N | Non-synonymous | TOLERATED | Yes |
KhiPS4F8 | 1 | 205153901 | FAIM3 | TTC-aTC | F67I | Non-synonymous | DAMAGING | Yes |
KhiPS4F8 | 5 | 121215932 | FTMT | CAC-CAt | H125H | Synonymous | NA | Yes |
KhiPS4F8 | 14 | 62486817 | KCNH5 | GAC-aAC | D386N | Non-synonymous | TOLERATED | No |
NSChiPS2F | 5 | 79774746 | ZFYVE16 | TCT-TaT | S823Y | Non-synonymous | DAMAGING | No |
NSChiPS2F | 12 | 54853783 | SMARCC2 | CCA-CCg | P538P | Synonymous | NA | Yes |
HUVhiPS4F1 | 2 | 169809670 | LRP2 | TCG-TtG | S1070L | Non-synonymous | TOLERATED | Yes |
HUVhiPS4F1 | 10 | 33542444 | NRP1 | GGC-GaC | G497D | Non-synonymous | DAMAGING | No |
HUVhiPS4F1 | 16 | 17139792 | XYLT1 | AAG-AgG | K562R | Non-synonymous | TOLERATED | No |
HUVhiPS4F1 | 4 | 155376303 | DCHS2 | GGA-GtA | G2529V | Non-synonymous | DAMAGING | No |
HUVhiPS4F3 | 6 | 155183150 | RBM16 | GTA-cTA | V595L | Non-synonymous | TOLERATED | No |
HUVhiPS4F3 | 9 | 394921 | DOCK8 | TCA-aCA | S1012T | Non-synonymous | TOLERATED | Yes |
HUVhiPS4F3 | X | 109889590 | CHRDL1 | CTT-aTT | L86I | Non-synonymous | TOLERATED | No |
HUVhiPS4F3 | 19 | 7475243 | C19orf45 | TCA-TaA | S229* | Nonsense | NA | Yes |
MSChiPS4F4 | 1 | 35998698 | CLSPN | GTG-tTG | V471L | Non-synonymous | TOLERATED | Yes |
MSChiPS4F4 | 1 | 153185686 | PBXIP1 | GAC-GgC | D363G | Non-synonymous | TOLERATED | Yes |
MSChiPS4F4 | 2 | 154960801 | GALNT13 | GAA-GAg | E403E | Synonymous | NA | Yes |
MSChiPS4F4 | 5 | 126704124 | MEGF10 | GTC-GTg | V74V | Synonymous | NA | Yes |
MSChiPS4F4 | 6 | 130572400 | SAMD3 | ATG-tTG | M106L | Non-synonymous | DAMAGING | Yes |
MSChiPS4F4 | 10 | 42974297 | CSGALNACT2 | ATG-gTG | M264V | Non-synonymous | TOLERATED | Yes |
MSChiPS4F4 | 11 | 36473107 | TRAF6 | GAA-aAA | E225K | Non-synonymous | DAMAGING | Yes |
MSChiPS4F4 | 17 | 50475673 | STXBP4 | GTA-GTg | V236V | Synonymous | NA | Yes |
MSChiPS4F4 | 19 | 40938581 | HSPB6 | TCGCCG-TCatCG | S84S P85S | Synonymous Non-synonymous | NA DAMAGING | No |
MSChiPS4F4 | 20 | 46706999 | PREX1 | GCC-GCt | A703A | Synonymous | NA | Yes |
MSChiPS4F4 | 21 | 39493296 | BRWD1 | AAA-AtA | K1639I | Non-synonymous | DAMAGING | Yes |
MSChiPS4F4 | X | 11688927 | MSL3 | TCT-TtT | S111F | Non-synonymous | DAMAGING | Yes |
MSChiPS4F8 | 1 | 39703363 | MACF1 | GGC-tGC | G5698C | Non-synonymous | DAMAGING | Yes |
MSChiPS4F8 | 1 | 158594563 | NCSTN | TTG-cTG | L670L | Synonymous | NA | No |
MSChiPS4F8 | 1 | 231873806 | KCNK1 | GAC-GAt | D224D | Synonymous | NA | Yes |
MSChiPS4F8 | 2 | 21087987 | APOB | CAC-CgC | H1753R | Non-synonymous | DAMAGING | Yes |
MSChiPS4F8 | 2 | 234287122 | UGT1A8 | GTC-GaC | V249D | Non-synonymous | NA | Yes |
MSChiPS4F8 | 5 | 128390915 | SLC27A6 | GAC-GAa | D482E | Non-synonymous | DAMAGING | No |
MSChiPS4F8 | 8 | 16079769 | MSR1 | CCG-tCG | P34S | Non-synonymous | TOLERATED | Yes |
MSChiPS4F8 | 9 | 125834763 | LHX2 | GAG-tAG | E393* | Non-synonymous | NA | No |
MSChiPS4F8 | 14 | 46496570 | MDGA2 | TTG-aTG | L318M | Non-synonymous | TOLERATED | Yes |
MSChiPS4F8 | 15 | 37669438 | THBS1 | TGC-TGt | C689C | Synonymous | NA | Yes |
MSChiPS4F8 | X | 152498688 | ATP2B3 | TCC-TaC | S1134Y | Non-synonymous | DAMAGING | Yes |
