Figure 8: Clinical relevance of the miR-30c signalling pathway.
From: MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11
(a) Scatter plots between IL-11 single gene expression and the expression of miR-30c in breast cancer data set with combined expression profiles of mRNA GSE22220 and miRNA GSE22216 (n=210). Pearson’s correlation was estimated (P=0.005). (b) Survival outcomes of IL-11 gene expression in primary breast cancers in the UNC337 publicly available microarray data set 8. Relapse-free survival KM plots were based on IL-11 gene expression and median gene expression was used to define low and high expressers (P=0.000109, n=337). (c) Signalling pathway scheme GATA3-miR30-TWF1-IL-11 regulation of breast cancer chemo-resistance.
