Figure 4: Structure of the LeuRSEc·tRNALeu·TM84 inhibition complex.
From: Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase
(a) Domain structure of LeuRSEc. (b) Structure of LeuRSEc·tRNALeu·TM84 complex in ‘aminoacylation-like’ conformation. Domains coloured and labelled, tRNALeu (blue) with Ade76 and TM84 depicted with stick bonds in synthetic active site. (c) Active site interactions with TM84. (d) Encapsulation of TM84 (space filling model—pink) in synthetic active site. LeuRSEc protein surface—grey and tRNALeu—blue.
