Figure 5: Comparison of TM84 and Leu-AMS bound in LeuRSEc ternary complexes.
From: Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase
(a) TM84 (pink) binding in the synthetic active site showing interactions with the KMSKS loop (gold) and the terminal tRNA Ade76 (blue). The ribose of the adenosine is in the C2′-endo conformation. Water molecule depicted as a red sphere. (b) Leu-AMS (grey) in its respective ternary complex. The ribose of the adenosine in this structure is in the C2′-exo conformation. (c) Superimposition of the two ligands in their respective ternary complexes.
