Table 1 Clinical and laboratory characteristics.

From: Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals

 

Patients with mild disease (51)

Patients with severe disease (32)

P -value

  

Total

Survived (19)

Died (13)

 

Age (years)

24.55±13.92

38.45±18.06

34.72±20.48

44.54±11.59

0.001

Gender (female/male)

22/29

11/21

6/13

5/8

0.427

Complications

—

32/32 (100%)

19/19 (100%)

13/13 (100%)

<0.001

 Consolidation and infiltrates on chest X-ray

—

31/32 (96.9%)

18/19 (94.73%)

13/13 (100%)

<0.001

 Respiratory failure

—

14/32 (43.8%)

8/19 (42.1%)

6/13 (46.2%)

<0.001

 ARDS

—

10/32 (31.3%)

3/19 (15.8%)

7/13 (53.8%)

<0.001

 DIC

—

3/32 (9.4%)

0/19 (0%)

3/13 (23.1%)

0.054

 Renal failure

—

2/32 (6.3%)

2/19 (10.5%)

0/13 (0%)

0.146

WBC ( × 109)

5.16±1.93

7.19±4.11

7.19±3.47

7.19±5.29

0.019

NEU%

53.51±14.51

77.38±15.22

74.76±17.43

82.10±9.11

<0.001

NEU absolute counts ( × 109)

2.93±1.77

5.57±3.42

5.41±3.09

5.86±4.12

0.001

Lymphocytes%

35.46±13.83

15.44±9.42

17.13±10.90

12.41±5.06

<0.001

Lymphocytes absolute counts ( × 109)

1.68±0.69

1.07±0.85

1.17±0.91

0.88±0.74

0.001

ALT>40 IU/l

1/51 (2.0%)

14/32 (43.8%)

7/19 (36.84%)

7/13 (53.84%)

<0.001

Hypokalemia

2/51 (3.9%)

10/32 (31.3%)

8/19 (42.10%)

2/13 (15.38%)

0.001

Length of hospital stay

5.9±2.1

17.3±12.0

  

<0.05

  1. WBC, white blood cells; NEU, neutrophil; ARDS, acute respiratory distress syndrome; DIC, disseminated intravascular coagulation; ALT, alanine aminotransferase.
  2. P-value refers to difference between mild and all severe patients.
  3. ARDS defined as a clinical syndrome comprising acute onset of dyspnoea (respiratory rate>28/min) and PaO2/FiO2<200 mm Hg with bilateral infiltrates on chest X-ray.
  4. Respiratory failure was defined as PaO2/FiO2<200 mm Hg.
  5. ‘Complications’ refer to features in the five rows listed below ‘Complications’.
Back to article page