Table 3 Association of rs12252 to severe infection under different genetic models.

From: Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals

Genetic model

 

Contingency table

P -value ( χ 2 approximately)

P -value (Fisher’s exact)

OR (95% CI)

General/genotypic

 

CC

CT

TT

0.0005267

0.0004788

Heterozygote: 6.56 (2.33–18.5)

Additive

Severe infection

22

8

2

0.0006196*

—

Homozygote: 5.92 (1.07–32.9)

 

Mild infection

13

31

7

   

Allelic/multiplicative

 

C

T

 

0.0008075

0.0007936

3.42 (1.63–7.17)

 

Severe infection

52

12

    
 

Mild infection

57

45

    

Dominant

 

CC+CT

TT

 

0.2864

0.4712

2.39 (0.46–12.3)

 

Severe infection

30

2

    
 

Mild infection

44

7

    

Recessive

 

CC

CT+TT

 

0.0001026

0.000201

6.43 (2.42–17.1)

 

Severe infection

22

10

    
 

Mild infection

13

38

    
  1. CI, confidence interval; OR, odds ratio.
  2. *Uses Cochran-Armitage test for trend.
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