Figure 8: Ghrelin attenuates haloperidol-induced catalepsy in vivo.
From: Peptide hormone ghrelin enhances neuronal excitability by inhibition of Kv7/KCNQ channels
(a) Effects of ghrelin on postural behaviour in rats receiving systemic administration of haloperidol. The line graph shows the scores of deviated posturing in rats recorded in 60 min after microinjection of ghrelin (1,000 nM, 0.5 μl), XE991 (1 μM, 0.5 μl) or retigabine (5 μM, 0.5 μl) into the SNc. (b) Time course of the bar tests shows that microinjection of ghrelin or XE991 into the SNc significantly attenuated the descent latency time in haloperidol-induced catalepsy rats (n=7. Each bar represents the mean±s.e.m. **P<0.01, Ghrelin versus Control; XE991 versus Control; non-parametric one-way Kruskal–Wallis test followed by the Mann–Whitney test).
