Figure 1: Characteristics of Myc-associated genes.

(a) Examples of Myc-associated genes. The signal for Myc is represented as the number of raw reads from ChIP-seq, and the signal for RNAPII is represented by the log2 enrichment from ChIP-chip. On the gene track, the genes above the line are transcribed from the plus strand and the genes below the line are transcribed from the minus strand. The two arrows on the left point to two protein-coding genes associated with Myc that also show high accumulation of RNAPII at the TSS. The two arrows on the right point to two non-protein-coding microRNA genes associated with Myc. (b) Genome-wide distribution of Myc-binding sites with respect to various gene landmarks. Distal intergenic region means regions that are at least 200 bp away from genes. (c) Cumulative curve of pausing index for all coding genes in the genome (black) or coding genes associated with Myc (green). The two distributions are significantly different (K-S test, P<2 × 10⁻¹⁶). (d) Distribution of expression levels of Myc target genes. All genes in the genome were sorted according to their expression score and binned into five groups (Group 1 with the lowest expression and Group 5 with the highest expression). Myc target genes were assigned to one of the groups if their expression scores fall into the range of expression levels for that group.