Figure 2: A subset of Myc sites at non-promoter regions have characteristics of enhancers. | Nature Communications

Figure 2: A subset of Myc sites at non-promoter regions have characteristics of enhancers.

From: A subset of Drosophila Myc sites remain associated with mitotic chromosomes colocalized with insulator proteins

Figure 2

(a) Examples of non-promoter Myc sites in the genome. The signals on the tracks of Myc, H3K4me1, H3K27ac and H3K4me3 are represented by the raw reads from ChIP-seq. The signal for RNAPII is represented by the log2 value from ChIP-chip. The arrows represent two Myc sites that display enhancer chromatin signatures (presence of H3K4me1/H3K27ac and absence of H3K4me3). (b) Heatmaps showing the chromatin features at promoter and non-promoter Myc sites. Each panel represents 2 kb upstream and downstream of the Myc sites. The sites are ordered by signal of H3K4me1. (c) Heatmaps showing chromatin features at all identified enhancers in Kc cells. The sites are ordered by signal of Myc. (d) Fraction of genes containing Myc at the promoter or enhancer expressed at different levels compared with all genes in the genome. Group 1 genes are expressed at low levels and Group 5 genes at the highest levels (see Methods).

Back to article page