Figure 4: Properties of Myc sites in interphase and mitotic chromosomes.
(a) Heatmap showing signals of Myc in interphase or mitosis at all the Myc site in the genome. The information indicates the existence of two groups of Myc sites in the genome, one is interphase-specific (Class I) and the second one is common to interphase and mitosis (Class II). (b) Binding intensity at Myc sites during interphase or mitosis plotted from the information displayed in panel a. The x axis represents distance from Myc sites and ‘0’ is the summit of Myc sites. Negative values indicate upstream and positive values indicate downstream of the Myc sites. (c) Usage of different binding motifs by the Myc protein in interphase (Class I) or mitosis (Class II). The significance of this difference was tested by the χ2-test for each motif (**P<0.01, *P<0.05).
