Figure 4: Fibrillar Aβ load is significantly increased in high-dose smoke treated-animals.
From: Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease
Epifluorescent microscopic images of ThS staining shown in cortex (a), hippocampus (b), and subiculum (c) of control, low-dose and high-dose cigarette smoke-treated mice. The burden of ThS-positive amyloid plaques was increased in high-dose-treated mice in both cortical areas (d) and hippocampus (e) compared with control and low-dose age-matched mice. However, no significant changes were observed in the subicular area (f). I–VI: cortical layers; cc: corpus callosum; so: stratum oriens; sp: stratum pyramidale; sr: stratum radiatum; slm: stratum lacunosum molecular; spm: stratum polymorphic; pcl: pyramidal cell layer; sm: stratum moleculare. Data (mean±s.e.m.) was analysed by one-way ANOVA followed by Tukey’s multiple comparison test (n=5–6 animals/group, four sections per animal). Scale bar: 50 μm. *P<0.05.
