Figure 6: Reactive astrogliosis is augmented in high-dose smoke-treated animals.
From: Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease
Light microscopic images of GFAP-immunoreactivity (specific for astroglial cells) shown in cortex (a) and hippocampus (b) of control, low-dose and high-dose cigarette smoke-treated mice. High magnification images of GFAP-stained reactive astroglial cells (arrows) in the cortical area of control (c) and high-dose groups (d). Immunostained astrocytes were increased in high-dose-treated mice in both cortical area (e) and hippocampus (f) compared with control and low-dose age-matched mice. I–VI: cortical layers; cc: corpus callosum; so: stratum oriens; sp: stratum pyramidale; sr: stratum radiatum; slm: stratum lacunosum moleculare. Data (mean±s.e.m.) was analysed by one-way ANOVA followed by Tukey’s multiple comparisons test. n=5–6 animals/group, four sections per animal. Scale bar: 50 μm (a–b), 25 μm (c–d). **P<0.01; *P<0.05.
