Figure 4: Comparison of affinity approaches with bisulphite sequencing.
From: Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing
(a) UCSC Genome Browser snapshots of TAmC-Seq, MeDIP-Seq and methylC-Seq near the DACH1 tumour suppressor locus. (b) Density plots of affinity enrichment compared with bisulphite sequencing at low CpG promoters (LCP, top), intermediate CpG promoters (ICP, middle) and high CpG promoters (HCP, bottom). (c) The distribution of affinity enrichment at promoters with low methylation (≤25% mCG, green) and high methylation (>75%, blue), as determined by bisulphite sequencing.
