Figure 7: Conformation-sensitive agonist activity of cell-released oligomeric α-synuclein for TLR2. | Nature Communications

Figure 7: Conformation-sensitive agonist activity of cell-released oligomeric α-synuclein for TLR2.

From: Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

Figure 7

(a) Separation of αSCM by SEC. The line trace and the bars indicate TLR2 activity and the α-synuclein levels, respectively. (b) Dot blot analysis of fractions from a. (c) MHC II fluorescence in the cerebral cortices of WT and Tlr2−/− mice after injections of fraction 8 and fraction 14 from a (n=5). Data were analyzed using unpaired t-test. Error bars represent ±s.e.m. *P<0.05; **P<0.01. ‘n’ represents the number of animals.

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