Figure 8: TLR2 expression in DLB and α-synuclein transgenic mice. | Nature Communications

Figure 8: TLR2 expression in DLB and α-synuclein transgenic mice.

From: Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

Figure 8

(a) Immunohistochemical analysis of human (top panels, n=6) and mouse samples (bottom panels, n=6). The TLR2 antibody-immunolabelled neuronal cells (N) as well as microglial cells (arrow heads). (b) Double immunofluorescence studies with antibodies against TLR2 and Iba-1 showing colocalization of the two markers in microglial cells (top panels). Double labelling for TLR2 and α-synuclein in the α-synuclein transgenic mice (bottom panels). (c) Western analysis of brain homogenates. All data were analysed using unpaired t-test. Error bars represent ±s.e.m. *P<0.05; **P<0.01. ‘n’ represents the number of patients and animals.

Back to article page