Figure 3: Aldara induces abscess-like structures and neutrophil recruitment. | Nature Communications

Figure 3: Aldara induces abscess-like structures and neutrophil recruitment.

From: Aldara activates TLR7-independent immune defence

Figure 3

(a) Representative staining of abscess-like structures with apoptotic cells in the epidermis of WT129 mice; Hematoxylin and eosin (H&E) (left), TUNEL (middle) and Ly6G (right), 24 h after 1 × Aldara. Scale bar, 50 μm. (b) Representative images of Ly6G staining at various time points after Aldara treatment of WT129 mice. Scale bar, 50 μm. Display of fold increases in mRNA expression levels of Aldara-treated skin compared with untreated skin of S100A8 (c), S100A9 (d), Cxcl1 (e), Il-17A (f) and Il-23 (g) in the skin of WT129, A129, C57BL/6 and TLR7-ko, assessed by qPCR 24 h after one topical Aldara treatment. Statistical significance displayed for ΔCT values of Aldara-treated compared with untreated samples of the same strain; *P<0.05, **P<0.01, ***P<0.001 (unpaired Student’s t-test).

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