Figure 8: Model for the role of Plin1 in regulating Fsp27-mediated lipid transfer and LD growth.
From: Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes
When Fsp27 is enriched at the LD contact site, it may adapt two conformations: the monomeric conformation that is inactive and the homodimeric conformation that is active in promoting lipid exchange, net lipid transfer and LD growth. Plin1 interacts with Fsp27 at the CIDE-N domain and changes the conformation of Fsp27, resulting in a restoration of the activity of CIDE-N monomeric inactive Fsp27 and an enhancement of the activity of dimeric Fsp27.
