Table 1 Tests of association by histological subtype for directly genotyped and imputed SNPs at 17q21.31 most strongly associated with invasive epithelial ovarian cancer risk among Europeans.

SNP Major>minor allele	Coordinate*	MAF	Subtype	Number of cases (versus 23,491 controls)	Per-allele OR (95% CI)†	P -value
rs1052587‡	44102604	0.22	All invasives	14,533	1.10 (1.06–1.13)	1.9 × 10⁻⁷
(T>C)			Serous	8,371	1.12 (1.08–1.17)	4.6 × 10⁻⁸
			Endometrioid	2,068	1.11 (1.04–1.19)	5.2 × 10⁻³
			Clear cell	1,025	0.98 (0.88–1.09)	0.68
			Mucinous	944	1.07 (0.96–1.20)	0.22
rs12942666§	43499839	0.22	All invasives	14,533	1.11 (1.07–1.15)	3.3 × 10⁻⁸
(A>G)			Serous	8,371	1.15 (1.11–1.20)	1.0 × 10⁻⁹
			Endometrioid	2,068	1.10 (1.02–1.18)	0.04
			Clear Cell	1,025	1.04 (0.92–1.14)	0.61
			Mucinous	944	1.04 (0.92–1.16)	0.55
rs2960000\|\|	43534353	0.18	All invasives	14,533	1.12 (1.08–1.16)	4.2 × 10⁻⁹
(T>C)			Serous	8,371	1.16 (1.12–1.20)	3.3 × 10⁻¹⁰
			Endometrioid	2,068	1.12 (1.03–1.20)	0.01
			Clear cell	1,025	1.05 (0.93–1.16)	0.44
			Mucinous	944	1.03 (0.90–1.15)	0.65

Abbreviations: CI, confidence interval; MAF, minor allele frequency in controls; OR, odds ratio.
^*Genome build NCBI B37/human genome build 19 assembly.
^†OR and 95% CI per copy of the minor allele, with adjustment for the first five eigenvalues from principal components analysis.
^‡rs1052587 is the most statistically significant miRNA-binding site SNP among all invasives and serous; it resides in a putative miRNA-binding site between microtubule-associated protein tau (MAPT) and miR-34a-5p (chr 1:9134225-9134425).
^§rs12942666 is a SNP at 17q21.31 that was directly genotyped as part of COGS; it is in strong linkage disequilibrium (r²=0.99) with two other 17q21.31 SNPs that were directly genotyped but had less optimal clustering: rs2077606 (P=3.9 × 10⁻¹⁰ for the serous subtype) and rs17631303 (P=4.7 × 10⁻¹⁰ for the serous subtype).
^||rs2960000 represents the most statistically significant SNP at 17q21.31 (among all invasives) that was imputed from the 1000 genome Project reference panel with an R-squared quality metric of 95% or greater (http://www.1000genomes.org/page.php).

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