Figure 4: Defective Klf5Δ/Δ HSC/P homing is attributed to a post-translational decrease in membrane-bound β1- and β2-integrins. | Nature Communications

Figure 4: Defective Klf5Δ/Δ HSC/P homing is attributed to a post-translational decrease in membrane-bound β1- and β2-integrins.

From: Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking

Figure 4

(a) Expression of membrane β1- and β2-integrin in WT (empty bars) and Klf5Δ/Δ (solid bars) LSK BM cells as assessed by flow cytometry (normalized mean fluorescence intensity ratio). *P=0.03, **P=0.004, Student t-test, n=3 to 4 per group. (b) Representative example of immunoblot of β1- and β2-integrin expression of whole-cell lysates from WT and Klf5Δ/Δ LSK BM cells. Densitometric ratio analysis was calculated. (c) Expression of membrane β1- and β2-integrin in LSK BM cells from tet-off, Scl-tTA/WT (empty bars) or Scl-tTA/TRE-Klf5 mice (solid bars). *P=0.01, Student t-test, n=4 per group.

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