Figure 1: Gene expression network for alveolar type II markers in normal lung.
From: Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas
(a) Gene coexpression networks associated with surfactant protein markers and NKX2-1 in normal human lung tissues. Gene pairs that are significantly correlated are drawn as blue boxes connected by a line; PEBP4 is shown in yellow. Other type 2 pneumocyte markers are shown in orange. (b) Adjacent sections of three normal slides from different lung cancer patients (1101N, 1116N and 1137N) were stained for expression of SFTPD, SFTPB, PEBP4 protein and a negative control (−) (microscope magnification: × 100). Type 2 pneumocytes were stained for known markers SFTPD and SFTPB as well as PEBP4, which was identified as a candidate marker for type 2 pneumocytes in gene expression networks. These slides indicate that the same cells express both surfactant proteins and PEBP4 protein.
