Figure 2: Human lung adenocarcinoma tissue gene expression network.
From: Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas
(A) Significantly correlated gene pairs that were part of a three-gene clique were plotted (r≥+/−0.75). This analysis identified network motifs associated with mitosis, protein translation, stromal cells/invasion, inflammation and Clara cells. (B) Progression network of lung adenocarcinoma. Gene pairs with significantly correlated change (r≥+/−0.7) and significant change in mRNA gene expression level between normal lung and adenocarcinomas are drawn as nodes (false discovery rate<5%, fold-change≥2). Red nodes indicate increased expression and green nodes indicate decreased expression, with darker colour indicating more extreme change. Grey lines connect genes with significant direct correlated change and red lines indicate inverse correlation. a, Clara cell and collagen motifs; b, cell cycle motif; c, type II pneumocyte motif.
