Figure 4: VRK1 correlation network in adenocarcinomas.
From: Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas
(a) Gene pairs that are significantly correlated with VRK1 (highlighted in yellow) are drawn as in Fig. 4. This network is significantly enriched for genes that function in the M-phase of mitosis. (b) mRNA gene expression of VRK1, AURKA and CCNB2 in normal lung and matched tumour tissues. Box plot displaying fold-change values for matched lung adenocarcinoma and normal lung tissue for three genes: VRK1, Aurora Kinase A (AURKA) and Cyclin B 2 (CCNB2). The mean increase in gene expression between normal and matched tumour samples is smaller in VRK1 than in AURKA and CCNB2.
