Table 1 Differential correlation analysis of NKX2-1.

Symbol	Probe	rho_normal	rho_tumor	Difference
BCAM	ILMN_1790455	−0.10	0.64	0.74
INTS5	ILMN_1796968	−0.02	0.72	0.74
ZNF323	ILMN_1655748	−0.07	0.64	0.71
*GGCX*	ILMN_1758232	0.06	0.72	0.66
*GLS2*	ILMN_1709771	0.08	0.73	0.65
ZNF323	ILMN_1679275	0.01	0.64	0.63
*GGTLC1*	ILMN_1692188	0.07	0.68	0.61
CDK6	ILMN_1802615	−0.11	−0.70	−0.59
*GGT2*	ILMN_1737387	0.09	0.68	0.59
*GGT1*	ILMN_1753340	0.05	0.64	0.59
CD163L1	ILMN_1661905	−0.05	−0.64	−0.59
STXBP1	ILMN_1728747	0.11	0.69	0.58
APLP2	ILMN_1710482	0.07	0.65	0.58
PRUNE	ILMN_1728914	0.08	0.64	0.56
CLPTM1L	ILMN_1752802	0.08	0.64	0.56
HOXD1	ILMN_1717381	0.10	0.66	0.56
GPD1L	ILMN_1694106	0.15	0.69	0.54
EXPH5	ILMN_1712066	0.18	0.72	0.54
GPR116	ILMN_1728785	0.14	0.68	0.54
ZDHHC9	ILMN_1734425	0.15	0.67	0.52
SALL2	ILMN_1740842	0.11	0.64	0.53
UBTD1	ILMN_1794914	0.15	0.67	0.52
TMEM150	ILMN_1765877	0.17	0.68	0.51

Listing of genes that fit the following criteria: i) significantly correlated with NKX2-1 in lung adenocarcinomas; ii) correlation of the same pair is ≥0.5 lower in normal lung tissue. This list is enriched for genes with roles in glutamine biosynthetic process (highlighted in bold).

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