Table 2 Top five canonical pathways of 1.5-fold upregulated genes in colonic EC from refed mice compared with refed mice treated with antibiotics.

From: Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice

Top canonical pathways

P -value *

Glycerolipid metabolism

1.04E-06

Metabolism of xenobiotics by cytochrome P450

2.23E-05

Linoleic acid metabolism

2.46E-05

LPS/IL-1-mediated inhibition of RXR function

3.33E-05

Arachidonic acid metabolism

3.24E-04

  1. *The generated canonical pathways were ranked by P-values, which were calculated using a Fisher’s exact test by comparing the number of the selected genes relative to the total number of occurrences of these genes in all functional/pathway annotations stored in the Ingenuity Pathways Knowledge Base.
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