Figure 2: Refinement of alcohol-binding site.
From: Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel
(a) Stereo view of protein atoms neighbouring one ethanol molecule (orange) in the co-crystal structure with GLIC F14′A. Dotted lines indicate putative hydrogen bonds with the backbone carbonyl of N200 in the left-hand subunit (dark grey) and with N15′ and E19′ in the right-hand subunit (light grey). (b) Protein atoms neighbouring one molecule of 2-bromoethanol (orange) in the co-crystal structure with GLIC F14′A, displayed as in a. Sigma-A-averaged electron density surrounding ethanol and 2-bromoethanol are contoured at 1.0 σ (blue mesh) and bromine-anomalous map is contoured at 5.0 σ (magenta mesh).
