Figure 7: Y26 phosphorylation of PGAM1 controls 3-PG and 2-PG levels to regulate biosynthesis and proliferation. | Nature Communications

Figure 7: Y26 phosphorylation of PGAM1 controls 3-PG and 2-PG levels to regulate biosynthesis and proliferation.

From: Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation

Figure 7

(a–e) Intracellular 3-PG (a) and 2-PG levels (b), RNA biosynthesis (c), lipogenesis (d) and cell proliferation rate (e) in H1299 cells expressing mPGAM1 Y26F mutant were measured, compared with control cells with rescue expression of mPGAM1 WT, in the presence and absence of cell permeable methyl-2-PG. The error bars represent mean values±s.d. from three independent experiments (*0.01<P<0.05; **P<0.01).

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