Figure 5: Nearby positive charges are unlikely to interact with the electrostatic surface potential of Phe481.
From: A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel
(a–e) GVs of Phe and fluorinated Phe derivatives incorporated at position 481 on the background of Lys380Cys (a), Arg387Gln (b), Lys390Gln (c), Arg394Gln (d) and Arg377Lys (e) (n=3–11 each, see also Supplementary Table S1); (f) ΔZFV1/2 values plotted against the number of fluorines for Phe and fluorinated Phe derivatives incorporated at position 481 on the background of Lys380Cys, Arg387Gln, Lys390Gln, Arg394Gln and Arg377Lys. Lines indicate linear fits obtained with f=y0+a*x, with y0=0 (mutants in black, WT in red). All data=mean±s.e.m.
