Figure 8: Proposed role for RORβ1 in amacrine and horizontal cell differentiation. | Nature Communications

Figure 8: Proposed role for RORβ1 in amacrine and horizontal cell differentiation.

From: An isoform of retinoid-related orphan receptor β directs differentiation of retinal amacrine and horizontal interneurons

Figure 8

It is proposed that RORβ1 and Foxn4 in progenitor cells cooperatively promote commitment to amacrine and horizontal cell fates by synergistic induction of Ptf1a. Ptf1a is transiently induced in post-mitotic precursors and consolidates the fates of both classes of interneurons. Many factors (not shown) contribute to the subsequent terminal differentiation of horizontal and amacrine cell sub-lineages, indicated here according to main neurotransmitter types (GABA, glycine, acetyl choline, dopamine, glutamate). Relative timing of expression of RORβ1, Foxn4 and Ptf1a is indicated on the right: Foxn4 is in dividing progenitors, Ptf1a in post-mitotic precursors and RORβ1 in both progenitors and precursors.

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