Table 3 Positively selected genes found in both humans and dogs.

From: The genomics of selection in dogs and the parallel evolution between dogs and humans

Gene

NS

Description

Genes involved in the digestion and metabolism

 ABCG5

4

ATP-binding cassette, sub-family G, member 5

 ABCG8

4

ATP-binding cassette, sub-family G, member 8

 PLA2G10

3

Phospholipase A2, group X

 PRSS1

6

Protease, serine, 1 (trypsin 1)

Genes involved in the neurological process

 GRM8

2

Glutamate receptor, metabotropic 8

 SLC6A4

4

Solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

Genes involved in cancer (including apoptosis and cell cycle)

 BFAR

3

Bifunctional apoptosis regulator

 BRE

2

Brain and reproductive organ-expressed (TNFRSF1A modulator)

 ITGB1

2

Integrin, beta 1

 MET

2

Met proto-oncogene (hepatocyte growth factor receptor)

 STK17B

5

Serine/threonine kinase 17b

 ZMYM2

6

Zinc finger, MYM-type 2

  1. Abbreviation: NS, number of human studies, which found evidence of positive selection in this gene.
  2. References are listed in the Supplementary Table S8. A full discussion can be found in the Supplementary Note 5.
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