Figure 4: Expression of the L-type calcium channels CaV1.2 and CaV1.3 in normal embryos.
From: Calfacilitin is a calcium channel modulator essential for initiation of neural plate development
(a–f) CaV1.2. Expression gradually becomes concentrated to neural plate precursors. (a) Mid-primitive streak stage (HH3+); (b) late primitive streak stage (HH4+); (c) early neurulation (HH6); (d) neural plate stage (HH7). (e,f) Sections through the levels indicated in (b,d), showing expression mainly in the epiblast. (g–j) In contrast, no significant expression of the CaV1.3 channel in seen in any embryonic region at primitive streak (g,h), neurulation (i) or neural tube (j) stages. Scale bar, 200 μm (a,b,g); Scale bar, 120 μm (c–f,h); Scale bar, 90 μm (i); Scale bar, 230 μm (j).
