Figure 8: A schematic model of regulation of lung cancer invasion and metastasis by miR-135b regulatory axis. | Nature Communications

Figure 8: A schematic model of regulation of lung cancer invasion and metastasis by miR-135b regulatory axis.

From: MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1

Figure 8

The expression level of miR-135b is regulated by DNA methylation and NF-κB activity. Once miR-135b is upregulated, it suppresses downstream target genes such as LZTS1 and Hippo pathways, therefore promotes tumor growth, EMT, invasion/metastasis and cancer stemness.

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