Figure 5: Ly-6B-expressing inflammatory macrophages (MØ) are M-CSF-dependent. | Nature Communications

Figure 5: Ly-6B-expressing inflammatory macrophages (MØ) are M-CSF-dependent.

From: Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation

Figure 5

Inflammatory (Inf) MØ were quantified 48 h after acute peritonitis induced with 2 × 106 zymosan particles in conjunction with 0.5 mg of either anti-M-CSF (clone 5A1) or and rat IgG isotype control. Neutralization of M-CSF results in a substantial drop in total Inf MØ numbers (left), which is caused by a near complete loss of Ly-6B+ Inf MØ (middle) and substantial drop in Ly-6B− Inf MØ (right). Data shown represent mean±s.e.m. of two independent experiments conducted with 7- to 8-week-old female C57BL/6 mice (n=5 per group) and one with 9- to 12-week-old female 129S6/SvEv (n=3–6 per group). Data were analysed by two-way ANOVA with the significance of the effects of both M-CSF and strain of mouse indicated.

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