Figure 5: Oligomer populations as a function of time.
From: Mechanistic and environmental control of the prevalence and lifetime of amyloid oligomers
The number of short fibrils, of ≤100 monomer units, plotted as a function of time (red squares); kinetic traces of the total fibril mass (normalized, right axes) are also shown (black lines). (a) At cp=0.2 mg ml−1, the protein concentration is below cT and a large number of short fibrillar species persist for long periods of time. (b) At cp=0.85 mg ml−1, a maximum in short species occurs at a time approximately coincident with the CFC being reached. Once the CFC is reached and the structural transition takes place, this population diminishes due to the suppression of fragmentation. The data are derived from stochastic simulations and are shown as the mean±s.d. of 150 replicate runs.
