Figure 6: XIAP protects the soma from caspase activation during axon-specific degeneration.
From: Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning
(a) Wild-type (WT) or XIAP-deficient neurons were locally deprived and probed for cleaved Casp6. Arrows indicate early signs of axonal collapse. Scale bar, 50 μm. Quantification of axon degeneration is shown on the right. (b) WT and XIAP-deficient neurons were NGF-maintained or locally deprived and cell bodies were probed for cleaved Casp3 (cC3). Nuclei were labelled with Hoechst. Scale bar, 20 μm. Quantification of the percentage of cell bodies positively labelled for cleaved Casp3 is shown on the right. All data represent the mean±s.e.m. (n=3). All P-values were calculated using an unpaired t-test.
