Figure 2: Structural determination of the FXR LBD in complex with ivermectin.
From: The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism
(a) The structure of ivermectin bound with FXR LBD in ribbon representation. FXR LBD is coloured in green and the NCoR-2 motif is in blue. The bound ivermectin is shown in stick representation with carbon and oxygen atoms depicted in yellow and red, respectively. (b) 2Fo-Fc electron density map (1.0σ) showing the bound ivermectin to the FXR LBD.
