Figure 6: Aberrant mapping of ipsilateral RGC axons.

(a) Schematic indicating the positions of parasagittal (1) and coronal (2-anterior, 3-posterior) sections through the SC depicted in (b) after full eye fills with CTB Alexa-488 (green, contralateral eye) and CTB Alexa-594 (magenta, ipsilateral eye). (b) Sections through the SC of wild-type mice (upper panels) at P8 show the ipsilateral projections (magenta) terminating discontinuously in only anterior positions of the SO below the dorsal-most SGS, which is occupied by contralateral projections (green). In lesion-induced mutant mice, two completely segregated TZs of ipsilateral RGC axons are found in the anterior and posterior SC (arrows). In addition, the terminations are not confined to the deeper SO, but are located incorrectly in the SGS. Dashed lines indicate border between SGS and SO, dashed-dotted lines indicate the dorsal SC border in (3). (n=4 wild-type controls, n=3 α-Del). A, anterior; D, dorsal; M, medial; P, posterior; R, rostral. Scale bar, 200 μm.