Table 1 The dissociation constant (Kd) of different peptides towards the binding of Grb2 or C-SH2 domain of Shp2.

From: Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2

Peptide name

Peptide sequence *

C-SH2 K d (μM)

Grb2 K d (nM)

pY542

KGHEpYTNIKYS

15.1±0.47

118±10.3

pY580

SARVpYENVGLM

294±23.6

68.5±8.7

  1. *All peptides contain a biotin-ASASA at their N termini.
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