Figure 1: Docking mode of the MAIT TCR in comparison with an NKT TCR that binds CD1d–lipid and a conventional TCR that binds MHC-I–peptide.
From: Recognition of vitamin B metabolites by mucosal-associated invariant T cells
(a) Left, MAIT TCR in complex with MR1–RL-6-Me-7-OH. MAIT TCR α-chain, cyan; MAIT TCR β-chain, salmon; CDR1α, purple; CDR2α, pink, CDR3α, yellow; CDR1β, teal; CDR2β, red; CDR3β, orange; RL-6-Me-7-OH, magenta; and MR1, grey. Middle, type I NKT TCR in complex with CD1d-lipid. NKT TCR α-chain, yellow; NKT TCR β-chain, green; lipid, magenta; CD1d, pale cyan; CDR loops colour coding as in a. Right, conventional TRAV1–2 TCR in complex with an MHC-peptide TCR α-chain, blue; TCR β-chain, brown; MHC, pale green; peptide, magenta; CDR loops colour coding as in a. (b) Left, MAIT TCR–MR1–RL-6-Me-7-OH complex; middle, NKT TCR–CD1d–lipid complex; and right, conventional TRAV1–2 TCR–MHC–peptide complex viewed down into the antigen-binding cleft. Black-filled circles indicate the centre of mass for the Vα and Vβ domains; CDR loops colour coding as in a. (c) Left, footprint of the MAIT TCR on the surface of MR1–RL-6-Me-7-OH; middle, footprint of the NKT TCR on the surface of CD1d–lipid; and right, footprint of the TRAV1–2 TCR on the surface of MHC–peptide. CDR loops colour coding as in a.
