Figure 3: Conformational flexibility of the MR1–antigen-binding cleft.
From: Recognition of vitamin B metabolites by mucosal-associated invariant T cells
(a) Antigen-binding cleft of MR1 with 6-FP bound. The surface is transparent to show 6-FP. (b) Cartoon overlay of the antigen-binding clefts of MR1–6-FP and MAIT TCR–MR1–6-FP. Movement of the MR1 α2 helix region 144–153 upon MAIT TCR binding is shown in red. (c) Left, antigen-binding cleft of MR1 within the MAIT TCR–MR1–6-FP complex. Right, antigen-binding cleft of MR1 within the MAIT TCR–MR1–RL-6-Me-7-OH complex. The surface is transparent. MR1, grey; 6-FP in MR1–6-FP, dark green; 6-FP in MAIT TCR–MR1–6-FP complex, green; RL-6-Me-7-OH, magenta; CDR3α, yellow.
